Eriksen returns to the starting line-up for Spurs this afternoon, replacing Lucas in the attacking third of the pitch, despite speculation regarding his future at the club.
Tottenham are still without the driving force of their Champions League win over City – Son Heung min, who is suspended. Dele Alli and Ryan Sessegnon are also injured.
City have made four changes to their side that beat West Ham. John Stones misses out with a thigh injuy and is replaced by Otamendi in the back four.
Gundogan comes into the midfield for David Silva, while Bernardo Silva and Aguero are recalled into the team to oust Mahrez and Jesus in the final third.
TOTTENHAM SUBS: Jan Vertonghen, Eric Dier, Giovano Lo Celso, Paulo Gazzaniga, Lucas Moura, Oliver Skipp, Ben Davies.
TOTTENHAM (4-3-2-1): Hugo Lloris; Kyle Walker-Peters, Davinson Sanchez, Toby Alderweireld, Danny Rose; Moussa Sissoko, Harry Winks, Tanguy Ndombele; Erik Lamela, Christian Eriksen; Harry Kane.
MANCHESTER CITY SUBS: Claudio Bravo, Gabriel Jesus, David Silva, Fernandinho, Riyad Mahrez, Joao Cancelo, Phil Foden.
MANCHESTER CITY (4-3-3): Ederson; Kyle Walker, Nicolas Otamendi, Aymeric Laporte, Oleksandr Zinchenko; Ilkay Gundogan, Rodri, Kevin De Bruyne; Bernardo Silva, Sergio Aguero, Raheem Sterling.